Explore comprehensive mapping of double-stranded RNA structures across the human genome. Our analysis using dsRNAscan identified 5,134,754 putative dsRNAs, providing insights into their structure, thermodynamics, conservation, and role in ADAR dependency.
dsRNA Browser
Interactive exploration of individual dsRNA structures with RNA structure probing data
Launch BrowserKey Findings
- 5,134,754 predicted dsRNAs across the human genome
- ~2.4 million high-confidence by three machine-learning models
- 1,591 conserved across vertebrates
- 769 sense–antisense gene pairs forming intermolecular dsRNAs (GFF3 download)
- dsRNA composition predicts ADAR dependency across cancer cell lines
The full 5,134,754 dsRNAs in two main formats: Parquet for analysis, BEDPE for genomic overlap.
Browse all downloads — sequences companion, GFF3 browser tracks, IGV arcs, high-confidence subsets, per-model variants, BEDPE subsets, tabix indexes. →Parquet — for analysis
Every analytical column (except RNA sequence and predicted structure). Reads in seconds with pandas, polars, or DuckDB.
Download dsRNA_human_v1.parquet (325 MB) Column dictionary (TSV) › Recipes: pandas / polars / DuckDB ›BEDPE — for bedtools pipelines
Each dsRNA as two intervals (i-arm + j-arm). Built for bedtools pairtobed
— overlap with genes, exons, repeats, ChIP peaks, etc.
Read the Preprint
Comprehensive Mapping of Human dsRNAome Reveals Conservation, Neuronal Enrichment, and Intermolecular Interactions
https://doi.org/10.1101/2025.01.24.634786
Code: github.com/Bass-Lab/dsRNAscan
Note: a revised manuscript is in preparation. The dataset and tools on this site reflect the most recent analysis, which may differ from the linked bioRxiv version.